Sildenafil Citrate ntsiav tshuaj 100 mg

Lub Npe Lub Npe: Sildenafil Citrate Tablets
Lub npe Askiv: Sildenafil Citrate ntsiav tshuaj
Cov khoom xyaw: Sildenafil Citrate
Cov tsos mob: Cov khoom no yog ib zaj duab xis - cov ntsiav tshuaj coated uas zoo nkaus li dawb rau tawm - dawb tom qab tshem tawm cov txheej.
Cov lus qhia: Sildenafil yog qhia rau kev kho mob ntawm erectile kawg.

Dosage thiab Administration:
1. Rau cov neeg mob feem ntau, cov koob tshuaj pom zoo yog 50 mg, noj raws li xav tau kwv yees li ib teev ua ntej kev sib deev; Txawm li cas los xij, nws tuaj yeem noj txhua lub sijhawm ntawm 0.5 thiab 4 teev ua ntej kev sib deev.
2. Raws li kev ua tau zoo thiab kev kam rau siab, koob tshuaj yuav nce mus rau 100 mg (qhov siab tshaj plaws pom zoo) lossis txo mus rau 25 mg. Kev noj tshuaj yuav tsum tau txwv rau ib zaug ib hnub. Sildenafil ntawm cov koob tshuaj pom zoo yog tsis muaj txiaj ntsig thaum tsis muaj kev sib deev stimulation . 3. Cov hauv qab no cuam tshuam nrog nce qib plasma sildenafil (AUC): hnub nyoog 65 xyoo lossis tshaj saud (40%), daim siab puas (xws li, cirrhosis, 80%), mob raum tsis zoo (creatinine clearance 30 ml / min), cytochrome P450 3A4 inhibitors (ketoconazole, itraconazole (200% nce), erythromycin (182%), saquinavir (210%). Vim tias cov ntshav plasma ntau dua tuaj yeem ua rau muaj txiaj ntsig zoo thiab qhov tshwm sim ntawm cov xwm txheej tsis zoo, qhov pib koob tshuaj ntawm 25 mg yog pom zoo rau cov neeg mob noj qab haus huv uas tsis muaj kab mob HIV. Ritonavir nce qib sildenafil plasma ntau ntau (AUC nce 11-fold; saib [Kev Sib Tham Tshuaj]). Yog li, nws raug pom zoo tias cov neeg mob noj Ritonavir ib txhij yuav tsum tsis txhob tshaj qhov koob tshuaj ntau tshaj 25 mg rau 48 teev. Sildenafil tuaj yeem txhim kho cov nyhuv antihypertensive ntawm nitrates. Yog li ntawd, cov neeg mob noj txhua yam ntawm nitric oxide pub thiab nitrate yuav tsum tsis txhob noj sildenafil. Yog tias sildenafil tau siv ua ke nrog alpha -blocker, tus neeg mob yuav tsum tau ua tiav cov txheej txheem alpha-blocker ruaj khov ua ntej pib kho sildenafil, thiab sildenafil yuav tsum tau pib ntawm qhov qis tshaj.

[Kev Tsis Pom Zoo]:
1. Hauv kev sim tshuaj thoob ntiaj teb, ntau dua 3,700 tus neeg mob (hnub nyoog 19 txog 87 xyoo) tau noj sildenafil. Ntau tshaj 550 ntawm cov neeg mob no tau kho ntau tshaj ib xyoos.
2. Hauv cov placebo- tswj kev sim tshuaj, tus nqi txiav tawm vim yog cov xwm txheej tsis zoo hauv pawg sim (2.5%) tsis txawv ntawm qhov ntawd hauv pawg placebo (2.3%). Cov xwm txheej tsis zoo feem ntau yog ib ntus thiab mob me mus rau nruab nrab hauv qhov xwm txheej.
3. Cov xwm txheej tsis zoo uas tau tshaj tawm los ntawm cov neeg mob hauv cov pab pawg sim yog feem ntau zoo sib xws thoob plaws txhua hom kev sim tshuaj. Hauv kev sim kho - koob tshuaj, qhov tshwm sim ntawm qee qhov xwm txheej tsis zoo tau nce ntxiv nrog kev siv tshuaj ntau ntxiv. Flexible -kev sim tshuaj feem ntau zoo dua tuaj yeem cuam tshuam txog lub sijhawm noj tshuaj pom zoo, thiab qhov xwm txheej tsis zoo uas tau pom hauv cov kev sim no zoo ib yam li tau pom nyob rau hauv cov kev sim tshuaj kho -.

[Contraindications]:
1. Vim nws paub cov teebmeem ntawm txoj kev nitric oxide/cGMP, sildenafil tuaj yeem txhim kho cov teebmeem ntawm cov tshuaj nitrates. Yog li ntawd, sildenafil yog contraindicated nyob rau hauv cov neeg mob noj cov nitrate formulation, tsis tu ncua los yog intermittently.
2. Tam sim no tsis paub meej tias thaum twg, tom qab noj sildenafil, cov neeg mob tuaj yeem noj nitrates zoo (yog tias tsim nyog). Raws li cov ntaub ntawv pharmacokinetic hauv cov neeg ua haujlwm noj qab haus huv, ib koob tshuaj ntawm qhov ncauj ntawm 100 mg ua rau cov ntshav plasma sildenafil concentrations kwv yees li 2 ng / mL (nce qib ntshav siab kwv yees li 440 ng / mL) 24 teev tom qab kev tswj hwm (saib [Pharmacokinetics]). Plasma sildenafil concentrations 24 teev tom qab kev tswj hwm yog 3-8 npaug ntau dua li cov neeg ua haujlwm noj qab haus huv hauv cov neeg mob hauv qab no: cov neeg muaj hnub nyoog 65 xyoo lossis tshaj saud, cov neeg uas muaj lub siab puas (xws li, cirrhosis), cov raum tsis zoo (creatinine clearance qis dua 30 ml / min), thiab cov neeg noj cov tshuaj cytochrome P450 3Aerymy inhibitors zoo li no. Txawm hais tias sildenafil plasma concentrations tom qab 24 teev tom qab kev tswj hwm tau qis dua qhov siab tshaj qhov siab, nws tsis paub tias nitrates tuaj yeem siv tau zoo nyob rau lub sijhawm no.
3. Cov khoom no yog contraindicated nyob rau hauv cov neeg mob uas paub hypersensitivity rau ib yam ntawm cov khoom xyaw.

[Cov kev ceev faj]:
General: Thaum kuaj pom erectile kawg, qhov tshwm sim hauv qab yuav tsum raug txheeb xyuas, thiab kev kho mob tsim nyog yuav tsum tau txiav txim siab tom qab kuaj xyuas tag nrho. Ua ntej muab cov tshuaj sildenafil rau cov neeg mob, cov lus qhia tseem ceeb hauv qab no yuav tsum tau sau tseg: Kev ceev faj yuav tsum tau siv thaum siv PDE5 (phosphodiesterase type 5) inhibitors nrog alpha-blockers. PDE5 inhibitors (nrog rau cov khoom no) thiab alpha-blockers yog ob qho tib si vasodilators thiab muaj txiaj ntsig ntawm kev txo cov ntshav siab. Thaum siv vasodilators ua ke, cov tshuaj ntxiv rau cov ntshav siab tuaj yeem xav tau. Hauv qee cov neeg mob, kev siv ob chav kawm ntawm cov tshuaj no tuaj yeem txo cov ntshav siab, ua rau cov tsos mob ntawm hypotension (xws li kiv taub hau, lightheadedness, syncope) (saib [Drug Interactions]). Cov hauv qab no kuj yuav tsum tau sau tseg: 1. Cov neeg mob yuav tsum tau ua tiav lub xeev ruaj khov ntawm alpha{13}}blocker kho ua ntej tau txais sildenafil. Cov neeg mob uas hemodynamically tsis ruaj khov thiab tab tom noj alpha{15}}blockers ib leeg yuav muaj kev pheej hmoo ntawm kev txhim kho hypotension nrog kev siv PDE5 inhibitors ua ke. 2. Cov neeg mob uas tau ua tiav lub xeev ruaj khov ntawm alpha{18}}blocker txoj kev kho yuav tsum pib nrog cov tshuaj qis tshaj ntawm PDE5 inhibitors{20} twb tau noj cov koob tshuaj zoo tshaj plaws ntawm PDE5 inhibitors yuav tsum pib nrog cov tshuaj qis tshaj ntawm alpha-blockers. Kev siv ua ke ntawm PDE5 inhibitors tuaj yeem txo cov ntshav siab ntxiv raws li alpha-blocker koob tshuaj maj mam nce ntxiv. 4. Kev nyab xeeb ntawm kev siv cov PDE5 inhibitors thiab alpha-blockers tuaj yeem cuam tshuam los ntawm lwm yam, suav nrog kev ntim hauv cov hlab ntshav thiab lwm yam tshuaj tiv thaiv ntshav siab. [Children's Precautions]: Tsis siv rau cov menyuam yaus
[Pregnancy and Lactation Precautions]: Tsis siv rau cov poj niam cev xeeb tub los yog lactating
[Cov Lus Ceeb Toom Cov Neeg Laus]: Sildenafil tshem tawm tau txo qis hauv cov neeg laus noj qab haus huv pab dawb (Ntau dua lossis sib npaug rau 65 xyoos)

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