Tadalafil hauv Pulmonary Hypertension
Tadalafil
Tadalafil (feem ntau paub los ntawm nws lub npeAdcirca®thaum muab tshuaj rau PH) yog ib qho dej zoo -tsim thiab siv qhov ncauj kho rau ib hom ntshav siab uas cuam tshuam rau cov hlab ntsha hauv lub ntsws.
To taub qhov xwm txheej
Pulmonary Arterial Hypertension (PAH) yog dab tsi?
Nws yog ib qho tseem ceeb kom paub qhov txawv Pulmonary Hypertension (ib lo lus dav) los ntawm Pulmonary Arterial Hypertension (ib kab mob tshwj xeeb).
Pulmonary Hypertension (PH):Ib lo lus dav dav rau ntshav siab hauv cov hlab ntsha uas txuas lub plawv mus rau lub ntsws (cov hlab ntsha pulmonary).
Pulmonary Arterial Hypertension (PAH):Ib qho tshwj xeeb, kev nce qib ntawm PH yam ntxwv los ntawm qhov nqaim thiab nruj ntawm cov hlab ntsha me me. Qhov no ua rau kom lub siab sab xis ntawm lub plawv yuav tsum ua haujlwm tawm tsam, thaum kawg ua rau lub plawv tsis ua haujlwm.
Tadalafil Ua Haujlwm li cas hauv PAH?
Tadalafil's mechanism yog tib yam li lwm yam xwm txheej -nws yog ib qhoPhosphodiesterase type 5 (PDE5) Inhibitor-tab sis nws lub hom phiaj yog nyob rau hauv lub ntsws cov hlab ntsha.
Cov txheej txheem ntuj tsim:Hauv lub ntsws, ib yam khoom hu uaNitric Oxide (NO)tso tawm kom pom cov hlab ntsha kom so thiab nthuav dav (vasodilation). Nws ua qhov no los ntawm kev nce qib ntawm cov neeg xa xov liaison hu uaCyclic guanosine monophosphate (cGMP).
Qhov teeb meem hauv PAH:Cov enzymePDE5rhuav tshem cGMP, txwv cov nyhuv vasodilating. Hauv PAH, qhov nyiaj tshuav no cuam tshuam, ua rau cov hlab ntsha tsis zoo.
Tadalafil Kev Ua Haujlwm:Tadalafil inhibits PDE5 enzyme. Qhov nokhaws cGMP qib, tso cai rau txhim kho thiab ntev vasodilation ntawm cov hlab ntsha pulmonary.
Qhov tshwm sim:So thiab widened pulmonary hlab ntsha ua rau:
Txo pulmonary arterial siab.
Txo tsis kam tiv thaiv uas lub plawv zoo yuav tsum tau tso.
Txhim kho cov ntshav ntws los ntawm lub ntsws.
Ua kom muaj peev xwm tawm dag zog.
Kev siv, kev siv, thiab pov thawj
Pom zoo siv:Tadalafil tau pom zoo rau kev kho mob ntawmLub Koom Haum Ntiaj Teb Kev Noj Qab Haus Huv (WHO) Pawg 1 Pulmonary Arterial Hypertension (PAH)los txhim kho kev muaj peev xwm tawm dag zog.
Standard Dosage:Qhov koob tshuaj pom zoo rau PAH yog40 mg ib hnub ib zaug. Qhov no tseem ceeb dua li cov koob tshuaj uas siv rau BPH(5 mg)los yog ED (5-20 mg). Nws tuaj yeem noj nrog lossis tsis muaj zaub mov.
Cov pov thawj kho mob:Kev sim tshuaj loj (xws li PHIRST txoj kev tshawb fawb) tau pom tias40 mg ntawm Tadalafilib hnub ib zaug txhim kho kev tawm dag zog lub cev ( ntsuas los ntawm qhov kev ncua deb taug kev hauv 6 feeb), txhim kho qhov chaw kho mob, thiab txo cov tsos mob.
Kev txiav txim siab tseem ceeb thiab kev nyab xeeb Profile
Cov teebmeem:Cov kev mob tshwm sim feem ntau cuam tshuam nrog nws cov vasodilating zog thiab zoo ib yam li cov uas pom nrog rau lwm yam kev siv, txawm hais tias lawv yuav hais tau ntau dua ntawm koob tshuaj 40 mg. Lawv suav nrog:
Mob taub hau
Flushing
Nasal congestion
Indigestion lossis heartburn
Cov leeg nqaij (myalgia)
Mob nraub qaum
Tsis Muaj Contraindications:
Nitrates:Kev sib xyaw ua ke nrog txhua hom ntawm cov organic nitrates (xws li nitroglycerin, isosorbide) yogtxwv tsis pub. Kev sib xyaw ua ke tuaj yeem ua rau mob hnyav thiab lub neej -kev hem thawj poob rau hauv cov ntshav siab.
Lwm yam tshuaj sib cuam tshuam:
Alpha{0}}blockers:Kev siv sib xyaw ua ke tuaj yeem ua rau ntshav siab.
Lwm yam vasodilators:Ntxiv ntshav siab-txo cov teebmeem yuav tshwm sim.
Riociguat (Adempas®):Cov tshuaj no ua haujlwm ntawm tib txoj kev. Ua ke nrog Tadalafil yog contraindicated vim muaj kev pheej hmoo ntawm hypotension hnyav.
Cov kev ceev faj:
Cov neeg mob uas mob siab lossis mob raum tsis zoo yuav xav tau kev hloov tshuaj lossis siv tsis tau cov tshuaj no.
Nws yuav tsum tau siv nrog ceev faj rau cov neeg mob uas muaj ntshav siab tsawg lossis cov neeg uas muaj keeb kwm ntawm kev tsis pom kev sai (NAION).
Cov ntsiab lus:
Tadalafil lub luag haujlwm hauv PAH Management
Tadalafil tau dhau los ua ib qhopob zeb pob zeb kho qhov ncaujrau PAH
Rau cov neeg mob:Nws muab kev yooj yim ntawm ib zaug - noj txhua hnub, txhim kho lub peev xwm ua haujlwm txhua hnub, thiab pab tswj tus kab mob.
Hauv Txoj Kev Kho Mob:Nws feem ntau yog siv los ua thawj - kab monotherapy rau qis dua - cov neeg mob raug mob lossis, nce ntxiv, ua ib feem ntawmpib ua ke kev kho mobnrog rau lwm yam PAH- cov tshuaj tshwj xeeb (xws li endothelin receptor antagonists) rau siab dua - cov neeg mob pheej hmoo ua rau mob hnyav.
Tswv yim: Koj Lub Hom Phiaj Kev Noj Qab Haus Huv Tus Kheej
Txhawm rau tiv thaiv tus txiv neej cov teeb meem kev noj qab haus huv, nco ntsoov cov ntsiab lus tseem ceeb hauv qab no:
Noj Ntse, Tsiv Ntau- Qhov no yog lub hauv paus ntawm kev noj qab haus huv.
Pw tsaug zog zoo, Tswj qhov hnyav- Qhov no yog lub cev kho thiab sib npaug mechanism.
Tsis txhob haus luam yeeb, haus tsawg dua- Qhov no yog kev nqis peev ntev - nyob rau hauv koj lub cev.
Tau txais kev txheeb xyuas tsis tu ncua-ups, Tshawb Pom ntxov- Nov yog daim ntawv ntse tshaj ntawm kev tiv thaiv tus kheej -.
Nyob zoo, tham tawm- Qhov no yog "software" ntawm kev noj qab haus huv.
Muaj Lub Hom Phiaj, Nyob Zoo- Qhov no yog qhov kawg tsav tsheb ntawm kev noj qab haus huv.
Kev noj qab haus huv tsis ua tiav thaum hmo ntuj; nws yog tsim los ntawm suav tsis txheeb me me, xaiv kom raug hauv lub neej txhua hnub. Pib hnub no los ntawm kev xaiv ib yam uas koj xav hloov thiab ua thawj kauj ruam. Koj lub neej yav tom ntej yog saib xyuas los ntawm koj tam sim no.
Peb Txoj Kev Them Nyiaj
Tiv tauj peb
Cim npe nrov: Tuam Tshoj tadalafil nyob rau hauv pulmonary hypertension manufacturers, lwm tus neeg